• Developmental delay, Intellectual disability or Autism
• Failure to thrive 
• Hypotonia / Spasticity
• Microcephaly / Macrocephaly
• Brain / Neurologic abnormalities
• Short stature, Skeletal dysplasia, Overgrowth, or Syndromic obesity
• Dysmorphic features / Birth defects
  
  

Adults

• Neurologic disorders (sensory and motor neuropathies)   
• Cardiomyopathies
• Hyperlipidemias
• Inherited eye, muscle or nerve disease
• Dementias
• Intellectual disability
• Family history of a genetic disorder

• Abnormal ultrasound findings - Urgent
• Positive Non-Invasive Prenatal Testing (NIPT)- Urgent
• Recurrent pregnancy loss
• Parental carrier screening
• Consanguinity
• History of Stillbirth
• Family or personal history of a genetic disorder
• Teratogen exposure
• Infertility
• Preconception counseling

• Personal or family history of early-onset cancer (<50 years)
• Personal or family history of known hereditary cancer syndrome (e.g., BRCA1/2, Lynch syndrome) 
• Personal history of ovarian, pancreatic, metastatic prostate, or triple-negative breast cancer diagnosed at any age